Cardioplegia Custodiol HTK Kӧhler Chemie GmbH Germany is intracellular ionic composed cardioplegia low K with the addition of three amino acids histidine tryptophan ketoglutarate and based on Bretschneiders solution introduced in 1975 5. Cardioplegia solution is the means by which the ischemic myocardium is protected from cell death.
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From a clinical point of view CUSTODIOL can be quicker perfused without any need for pressurized perfusion.
. Both are given as a single dose and offer myocardial protection for up to 2 hours. CUSTODIOL can be used right away and no further additives are needed. Inducing cardiac arrest usually implies slow infusion of the HTK solution at a temperature of 58 C into the coronary system with a hydrostatic pressure of 100 mmHg which corresponds to approximately 140 cm.
While UW provides lactobionate and raffinose Custodiol uses mannitol a very safe product. The delivery pressure for Custodiol is different from blood based cardioplegia due to its low viscosity which is similar to sterile water. Custodiol cardioplegia is an attractive solution for many cardiac surgeons as a single dose provides a long period of myocardial protection.
The cardioplegic solution was delivered at a temperature of 4C - 10C. After propensity-score matching we were able to match 71 Custodiol. Despite widespread use in Europe there is little data confirming its efficacy compared with conventional blood or.
HTK solution is intended for perfusion and flushing of donor liver kidney heart lung and pancreas prior to removal from the donor and for preserving these organs. A total of 1900 cardiac surgical procedures were identified of which 126 7 utilized Custodiol and 1774 93 used blood cardioplegia as the primary cardioplegic agent. A Single-Dose Hyperpolarizing Solution The impact of a low-sodium solution on electrophysiology physiology solutions composition and experimental results mode of administration clinical results and last but not least the take-home message is demonstrated step by step.
Custodiol histidine-tryptophanketoglutarate htk or bretschneiders solution is an intracellular crystalloid cardioplegia solution that is currently in use for myocardial preservation during. Another important aspect in this context is. The purpose of cardioplegia is to cause myocardial arrest to support normal physiology during ischemia and to decrease the metabolism.
Blood cardioplegia was administered in 88 571 patients and Custodiol cardioplegia was administered in 66 429 patients. The objective of this study was to compare its impact on myocardial function in infants. The title of my lecture is Custodiol Cardioplegia.
Histidine-tryptophan-ketoglutarate or Custodiol HTK solution is a high-flow low-potassium preservation solution used for organ transplantationThe solution was initially developed by Hans-Jürgen Bretschneider. CUSTODIOL preservation solution was used. CUSTODIOL HTK CARDIOPLEGIC SOLUTION Solution indicated for cardioplegia in connection with cardiosurgical operations organ protection during operations under ischemia heart kidney liver preservation of organ transplants heart kidney liver lung pancreas together with venous or arterial segments.
The objective of this study is to demonstrate that custodiol is not inferior to cold cardioplegic solution for myocardial protection by comparing standard cold blood cardioplegia to custodiol solution with respect to myocardial injury as measured by creatine phosphokinase mb isoenzyme ck-mbtroponin-i at 7 hours post surgery and changes in. Custodiol is an intracellular crystalloid cardioplegia solution that is a single-dose alternative to multi-dose cold blood cardioplegia. After cross-clamping of the aorta approximately 1-2 L of Custodiol-HTK was infused into the ascending aorta over 6-8 minutes.
The title of my lecture is Custodiol Cardioplegia. This is due to its comparatively low viscosity which equals the one of water 20 cP. Custodiol HTK Histidine-Trytophan-Ketoglutarate is a crystalloid cardioplegia an understanding of its function and delivery is essential.
Custodiol cardioplegia is attractive for minimally invasive cardiac surgery as a single dose provides a long period of myocardial protection. However there is scarce data regarding its use in infants and children. The low sodium allows for increased osmotic space for better buffering.
Custodiol is a low viscosity solution with low levels of potassium low enough that Custodiol need not be flushed out of the organ prior to implantation and sodium. Thomas 2 are appealing cardioplegic agents for minimal invasive cardiac surgery. The title of my lecture is Custodiol Cardioplegia.
Bretschneider Custodiol and St. Subsequent doses are delivered at 3-4 Degrees Celsius 10mlkg to a maximum of 1 liter. A Single-Dose Hyperpolarizing Solution The impact of a low-sodium solution on electrophysiology physiology solutions composition and.
CUSTODIOL HTK Solution is indicated for perfusion and flushing of donor kidneys liver pancreas and heart prior to removal from the donor or immediately after removal from the donor. The solution is left in the organ vasculature during hypothermic storage and transportation not for continuous perfusion to the recipient. Custodiol HTK based on its buffering capacity is often used as a single-dose product.
Additional doses of 100-200 ml were administered as needed. A Single-Dose Hyperpolarizing Solution The impact of a low-sodium solution on electrophysiology physiology solutions composition and experimental results mode of administration clinical results and last but not least the take-home message is demonstrated step by step. Propensity score matching was performed to correct for any bias that may have been associated with the usage of Custodiol.
Custodiol HTK Solution Cardioplegia Only solution used as Single Shot Cardioplegia for prolonged ishchemia No surface cooling No retrocardiac cooling No obligatory reperfusion High rate of spontaneous return to sinus rhythm Minimized cell necrosis Less depletion of ATP stores Remarkably increased. Custodiol HTK will be delivered at 3-4 Degrees Celsius 20 mlkg to a maximum of 2 liters for the initial dose. Aims We aimed to evaluate the benefit of custodiol cardioplegia in comparison with the conventional one in supporting training programs.
Results A total of 154 patients were included in the analysis this excludes two patients who met inclusion criteria but had significant missing variables. The blood cardioplegia group includes solutions such as Calafiore or Buckberg both with microplegia alternatives.
Pediagenosis Heart Valves Mitral Valve Repair Mitral Valve